Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapy.

ABSTRACT:

Objectives

To determine the incidence, clinical manifestations and risk factors for immune reconstitution inflammatory syndrome (IRIS) in young children initiating highly active antiretroviral therapy (HAART).

Design

A prospective cohort of antiretroviral-naïve HIV-infected children less than 24 months of age enrolled in a treatment strategies trial in Johannesburg, South Africa.

Methods

Among 169 HIV-infected children initiating HAART, April 2005 to November 2006, the records of 83 children suspected to have IRIS within 6 months of starting treatment were reviewed to determine whether they met criteria for IRIS. Seven were excluded due to incomplete follow-up. Pretreatment and post-treatment characteristics of children with and without IRIS were compared.

Results<

SUBMITTER: Smith K 

PROVIDER: S-EPMC2810152 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature