Implications of increased C-reactive protein for cardiovascular risk stratification in black and white men and women in the US.

ABSTRACT:

Background

We evaluated prevalence and correlates of increased high-sensitivity C-reactive protein (hsCRP) in a large population of blacks and whites, and the impact of hsCRP measurement on coronary heart disease risk reclassification.

Methods

We studied 19 080 participants of the REGARDS (REasons for Geographic And Racial Differences in Stroke) study (age >45 years, without vascular diagnoses, and living dispersed across the US). A total of 8309 nondiabetic participants not using lipid-lowering medications were classified into 4 risk categories based on the Framingham vascular disease risk score. Participants with hsCRP <1 mg/L were reclassified to the next lower risk group, and those with hsCRP >3 mg/L to the next higher risk group. We also assessed reclassification of ris

SUBMITTER: Cushman M 

PROVIDER: S-EPMC2810186 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature