Regulation of gene expression by PI3K in mouse growth plate chondrocytes.

ABSTRACT:

Background

Endochondral ossification, the process through which long bones are formed, involves chondrocyte proliferation and hypertrophic differentiation in the cartilage growth plate. In a previous publication we showed that pharmacological inhibition of the PI3K signaling pathway results in reduced endochondral bone growth, and in particular, shortening of the hypertrophic zone in a tibia organ culture system. In this current study we aimed to investigate targets of the PI3K signaling pathway in hypertrophic chondrocytes.

Methodology/principal findings

Through the intersection of two different microarray analyses methods (classical single gene analysis and GSEA) and two different chondrocyte differentiation systems (primary chondrocytes treated with a pharmacological inhi

SUBMITTER: Ulici V 

PROVIDER: S-EPMC2810323 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature