Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease.

ABSTRACT:

Background

Epidemiological data suggest that the male gender is one of the risks factors for the development of Parkinson Disease (PD). Also, differences in the clinical manifestation and the course of PD have been observed between males and females. However, little is known about the molecular aspects underlying gender-specificity in PD. To address this issue, we determined the gene expression profiles of male and female dopamine (DA) neurons in sporadic PD.

Methodology/principal findings

We analyzed Affymetrix-based microarrays on laser microdissected DA neurons from postmortem brains of sporadic PD patients and age-matched controls across genders. Pathway enrichment demonstrated that major cellular pathways involved in PD pathogenesis showed different patterns of deregula

SUBMITTER: Simunovic F 

PROVIDER: S-EPMC2810324 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature