Hydrosulfide (HS-) coordination in iron porphyrinates.

ABSTRACT: Recent reports of potential physiological roles of hydrogen sulfide have prompted interest in heme-sulfide interactions. Heme-H(2)S and/or heme-HS(-) interactions could potentially occur during endogenous production, transport, signaling events, and catabolism of H(2)S. We have investigated the interaction of the hydrosulfide ion (HS(-)) with iron porphyrinates. UV-vis spectral studies show the formation of [Fe(Por)(SH)](-), [Fe(Por)(SH)(2)](2-), and the mixed-ligand species [Fe(Por)(Im)(SH)](-). UV-vis binding studies of [Fe(OEP)] and [Fe(T-p-OMePP)] (OEP = octaethylporphyrinate; T-p-OMePP = tetra-p-methoxyphenylporphyrinate) with HS(-) allowed for calculation of the formation constants and extinction coefficients of mono- and bis-HS(-) complexes. We report the synthesis of the first HS(-

SUBMITTER: Pavlik JW 

PROVIDER: S-EPMC2811220 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature