A biology-based approach for mixture toxicity of multiple endpoints over the life cycle.

ABSTRACT: Typical approaches for analyzing mixture ecotoxicity data only provide a description of the data; they cannot explain observed interactions, nor explain why mixture effects can change in time and differ between endpoints. To improve our understanding of mixture toxicity we need to explore biology-based models. In this paper, we present an integrated approach to deal with the toxic effects of mixtures on growth, reproduction and survival, over the life cycle. Toxicokinetics is addressed with a one-compartment model, accounting for effects of growth. Each component of the mixture has its own toxicokinetics model, but all compounds share the effect of body size on uptake kinetics. The toxicodynamic component of the method is formed by an implementation of dynamic energy budget theory; a set o

SUBMITTER: Jager T 

PROVIDER: S-EPMC2811243 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature