Rational selection of gold nanorod geometry for label-free plasmonic biosensors.

ABSTRACT: We present the development of an analytical model that can be used for the rational design of a biosensor based on shifts in the local surface plasmon resonance (LSPR) of individual gold nanoparticles. The model relates the peak wavelength of light scattered by an individual plasmonic nanoparticle to the number of bound analyte molecules and provides an analytical formulation that predicts relevant figures-of-merit of the sensor such as the molecular detection limit (MDL) and dynamic range as a function of nanoparticle geometry and detection system parameters. The model calculates LSPR shifts for individual molecules bound by a nanorod, so that the MDL is defined as the smallest number of bound molecules that is measurable by the system, and the dynamic range is defined as the maximum numb

SUBMITTER: Nusz GJ 

PROVIDER: S-EPMC2811423 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature