A computer simulation of progesterone and Cox2 inhibitor treatment for preterm labor.

ABSTRACT:

Background

Sufficient information from in vitro and in vivo studies has become available to permit computer modeling of the processes that occur in the myometrium during labor. This development allows the in silico investigation of pathological mechanisms and the trialing of potential treatments.

Methods/results

Based on the human literature, we developed a computer model of the immune-endocrine environment of the myometrial cell. The interactions between molecules are represented by differential equations. The model is designed to simulate the estrogen and progesterone receptor changes during pregnancy and particularly the changes in the progesterone receptor (PR) isoforms A and B that are thought to mediate functional progesterone withdrawal in the human at labor. Parturit

SUBMITTER: Equils O 

PROVIDER: S-EPMC2811723 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature