Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling.

ABSTRACT: Despite the successful introduction of potent anti-cancer therapeutics, most of these drugs lead to only modest tumor-shrinkage or transient responses, followed by re-growth of tumors. Combining different compounds has resulted in enhanced tumor control and prolonged survival. However, methods querying the efficacy of such combinations have been hampered by limited scalability, analytical resolution, statistical feasibility, or a combination thereof. We have developed a theoretical framework modeling cellular viability as a stochastic lifetime process to determine synergistic compound combinations from high-throughput cellular screens. We apply our method to data derived from chemical perturbations of 65 cancer cell lines with two inhibitors. Our analysis revealed synergy for the combinati

SUBMITTER: Peifer M 

PROVIDER: S-EPMC2811738 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature