Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies.

ABSTRACT: A central issue in genome-wide association (GWA) studies is assessing statistical significance while adjusting for multiple hypothesis testing. An equally important question is the statistical efficiency of the GWA design as compared to the traditional sequential approach in which genome-wide linkage analysis is followed by region-wise association mapping. Nevertheless, GWA is becoming more popular due in part to cost efficiency: commercially available 1M chips are nearly as inexpensive as a custom-designed 10 K chip. It is becoming apparent, however, that most of the on-going GWA studies with 2,000-5,000 samples are in fact underpowered. As a means to improve power, we emphasize the importance of utilizing prior information such as results of previous linkage studies via a stratified fals

SUBMITTER: Yoo YJ 

PROVIDER: S-EPMC2811772 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature