Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza.

ABSTRACT:

Introduction

Human host immune response following infection with the new variant of A/H1N1 pandemic influenza virus (nvH1N1) is poorly understood. We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1.

Methods

We profiled 29 cytokines and chemokines and evaluated the haemagglutination inhibition activity as quantitative and qualitative measurements of host immune responses in serum obtained during the first five days after symptoms onset, in two cohorts of nvH1N1 infected patients. Severe patients required hospitalization (n = 20), due to respiratory insufficiency (10 of them were admitted to the intensive care unit), while mild patients had exclusively flu-like symptoms

SUBMITTER: Bermejo-Martin JF 

PROVIDER: S-EPMC2811892 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature