Mycobacterium tuberculosis modulates its cell surface via an oligopeptide permease (Opp) transport system.

ABSTRACT: Bacterial species utilize a vast repertoire of surface structures to interact with their surroundings and employ a number of strategies to reconfigure the cellular envelope according to specific stimuli. Gram-positive bacteria, exemplified by Streptomyces and Bacillus species, control production of some exposed molecules by importing oligopeptide signals via permeases (Opp). Such oligopeptides modulate intracellular signaling pathways. In this work, we functionally characterized an Opp of the human pathogen Mycobacterium tuberculosis (Mtb) and propose its reannotation. Using genome-wide transcriptional profiling, we found that Opp was required to modulate (fold-change ranging from -3.5 to 2.0) the expression of several genes, most of them encoding surface-exposed molecules. These included

SUBMITTER: Flores-Valdez MA 

PROVIDER: S-EPMC2812042 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature