Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.

ABSTRACT: Commensal bacteria possess immunostimulatory activities that can modulate host responses to affect development and homeostasis in the intestine. However, how different populations of resident bacteria stimulate the immune system remains largely unknown. We characterized here the ability of intestinal and oral microflora to stimulate individual pattern recognition receptors (PRRs) in bone marrow-derived macrophages and mesothelial cells. The intestinal but not oral microflora elicited age- and cell type-specific immunostimulation. The immunostimulatory activity of the intestinal microflora varied among individual mice but was largely mediated via Toll-like receptor 4 (TLR4) during breast-feeding, whereas it became TLR4 independent after weaning. This transition was associated with a change

SUBMITTER: Hasegawa M 

PROVIDER: S-EPMC2812188 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature