The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.

ABSTRACT: The innate immune response provides the first line of defense against foreign pathogens by responding to molecules that are a signature of a pathogenic infection. Certain RNA viruses, such as influenza virus, produce double-stranded RNA as an intermediate during the replication life cycle, which activates pathogen recognition receptors capable of inducing interferon production. By engaging interferon receptors, interferon activates the JAK-STAT pathway and results in the positive feedback of interferon production, amplifying the response to viral infection. To examine how deficiencies in interferon signaling affect the cellular response to infection, we performed influenza virus infections of mouse embryonic fibroblasts lacking the alpha/beta interferon receptor, the gamma interferon recep

SUBMITTER: Goodman AG 

PROVIDER: S-EPMC2812385 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature