Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis.

ABSTRACT:

Background

We present a systematic review and meta-analysis of the available clinical trials concerning the usefulness of aripiprazole in the treatment of the psychotic symptoms in bipolar disorder.

Methods

A systematic MEDLINE and repository search concerning clinical trials for aripiprazole in bipolar disorder was conducted.

Results

The meta-analysis of four randomised controlled trials (RCTs) on acute mania suggests that the effect size of aripiprazole versus placebo was equal to 0.14 but a more reliable and accurate estimation is 0.18 for the total Positive and Negative Syndrome Scale (PANSS) score. The effect was higher for the PANSS-positive subscale (0.28), PANSS-hostility subscale (0.24) and PANSS-cognitive subscale (0.20), and lower for the PANSS-negative sub

SUBMITTER: Fountoulakis KN 

PROVIDER: S-EPMC2812439 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature