Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems.

ABSTRACT: Androgen ablation therapy is currently the primary treatment for metastatic prostate cancer. Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer progression. As androgens like testosterone are withdrawn, prostate cancer cells lose their androgen sensitivity and begin to proliferate without hormone growth factors. In this study, we constructed and analyzed a mathematical model of the integration between hormone growth factor signaling, androgen receptor activation, and the expression of cyclin D and Prostate-Specific Antigen in human LNCaP prostate adenocarcinoma cells. The objective of the study was to investigate which signaling systems were important in the loss of androgen dependence. The model was formulated as a set of ordinary differential equatio

SUBMITTER: Tasseff R 

PROVIDER: S-EPMC2812491 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature