E. coli K-12 and EHEC genes regulated by SdiA.

ABSTRACT:

Background

Escherichia and Salmonella encode SdiA, a transcription factor of the LuxR family that regulates genes in response to N-acyl homoserine lactones (AHLs) produced by other species of bacteria. E. coli genes that change expression in the presence of plasmid-encoded sdiA have been identified by several labs. However, many of these genes were identified by overexpressing sdiA on a plasmid and have not been tested for a response to sdiA produced from its natural position in the chromosome or for a response to AHL.

Methodology/principal findings

We determined that two important loci reported to respond to plasmid-based sdiA, ftsQAZ and acrAB, do not respond to sdiA expressed from its natural position in the chromosome or to AHLs. To identify genes that are regulated by c

SUBMITTER: Dyszel JL 

PROVIDER: S-EPMC2812512 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature