The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects.

ABSTRACT: The nonclassical major histocompatibility complex (MHC) Qa-1b accommodates monomorphic leader peptides and functions as a ligand for germ line receptors CD94/NKG2, which are expressed by natural killer cells and CD8+ T cells. We here describe that the conserved peptides are replaced by a novel peptide repertoire of surprising diversity as a result of impairments in the antigen-processing pathway. This novel peptide repertoire represents immunogenic neoantigens for CD8+ T cells, as we found that these Qa-1b-restricted T cells dominantly participated in the response to tumors with processing deficiencies. A surprisingly wide spectrum of target cells, irrespective of transformation status, MHC background, or type of processing deficiency, was recognized by this T cell subset, complying with t

SUBMITTER: Oliveira CC 

PROVIDER: S-EPMC2812552 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature