Ontology highlight
ABSTRACT:
SUBMITTER: Nie D
PROVIDER: S-EPMC2812631 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Nature neuroscience 20100110 2
Tuberous sclerosis complex is a disease caused by mutations in the TSC1 or TSC2 genes, which encode a protein complex that inhibits mTOR kinase signaling by inactivating the Rheb GTPase. Activation of mTOR promotes the formation of benign tumors in various organs and the mechanisms underlying the neurological symptoms of the disease remain largely unknown. We found that Tsc2 haploinsufficiency in mice caused aberrant retinogeniculate projections that suggest defects in EphA receptor-dependent ax ...[more]