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The natural products beauveriolide I and III: a new class of beta-amyloid-lowering compounds.

ABSTRACT: Attacking Alzheimer's by ACAT: The aggregation of beta-amyloid peptides, especially Abeta(42), into senile plaques is a hallmark of Alzheimer's disease (AD). We show that the fungal natural products beauveriolides I and III can potently decrease Abeta secretion from cells expressing human amyloid precursor protein; this offers a potential new scaffold for the development of compounds with proven bioavailability for the treatment of AD.

SUBMITTER: Witter DP

PROVIDER: S-EPMC2812801 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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The natural products beauveriolide I and III: a new class of beta-amyloid-lowering compounds.

Witter Daniel P DP Chen Yanping Y Rogel Joseph K JK Boldt Grant E GE Wentworth Paul P

Chembiochem : a European journal of chemical biology 20090501 8

Attacking Alzheimer's by ACAT: The aggregation of beta-amyloid peptides, especially Abeta(42), into senile plaques is a hallmark of Alzheimer's disease (AD). We show that the fungal natural products beauveriolides I and III can potently decrease Abeta secretion from cells expressing human amyloid precursor protein; this offers a potential new scaffold for the development of compounds with proven bioavailability for the treatment of AD. ...[more]

PMID: 19396893

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