Predicting functional upstream open reading frames in Saccharomyces cerevisiae.

ABSTRACT:

Background

Some upstream open reading frames (uORFs) regulate gene expression (i.e., they are functional) and can play key roles in keeping organisms healthy. However, how uORFs are involved in gene regulation is not yet fully understood. In order to get a complete view of how uORFs are involved in gene regulation, it is expected that a large number of experimentally verified functional uORFs are needed. Unfortunately, wet-experiments to verify that uORFs are functional are expensive.

Results

In this paper, a new computational approach to predicting functional uORFs in the yeast Saccharomyces cerevisiae is presented. Our approach is based on inductive logic programming and makes use of a novel combination of knowledge about biological conservation, Gene Ontology annotations

SUBMITTER: Selpi 

PROVIDER: S-EPMC2813248 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature