Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery.

ABSTRACT:

Objective

Approximately 10% of patients undergoing cardiac surgery have perioperative myocardial injury. A recent genome-wide association study identified an association between myocardial infarction in nonsurgical populations and common genetic variants on chromosome 9p21. We hypothesized that these variants are also associated with perioperative myocardial injury after isolated primary coronary artery bypass graft surgery.

Methods

In a prospective observational study of 846 Caucasian patients undergoing primary coronary bypass surgery at 2 US centers, we genotyped 61 linkage-disequilibrium tagging single nucleotide polymorphisms, encompassing 436 kbp of the 9p21 region. A multivariable logistic model was used to adjust for previously identified clinical covariates of perio

SUBMITTER: Liu KY 

PROVIDER: S-EPMC2813396 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature