Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.

ABSTRACT: The genetic variants underlying the strong heritable component of prostate cancer remain largely unknown. Genome-wide association studies of prostate cancer have yielded several variants that have significantly replicated across studies, predominantly in cases unselected for family history of prostate cancer. Additional candidate gene variants have also been proposed, many evaluated within familial prostate cancer study populations. Such variants hold great potential value for risk stratification, particularly for early-onset or aggressive prostate cancer, given the comorbidities associated with current therapies. Here, we investigate a Caucasian study population of 523 independent familial prostate cancer cases and 523 age-matched controls without a personal or family history of prostate

SUBMITTER: Breyer JP 

PROVIDER: S-EPMC2813685 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature