Expression map of the human exome in CD34+ cells and blood cells: increased alternative splicing in cell motility and immune response genes.

ABSTRACT:

Background

Hematopoietic cells are endowed with very specific biological functions, including cell motility and immune response. These specific functions are dramatically altered during hematopoietic cell differentiation, whereby undifferentiated hematopoietic stem and progenitor cells (HSPC) residing in bone marrow differentiate into platelets, red blood cells and immune cells that exit into the blood stream and eventually move into lymphoid organs or inflamed tissues. The contribution of alternative splicing (AS) to these functions has long been minimized due to incomplete knowledge on AS events in hematopoietic cells.

Principal findings

Using Human Exon ST 1.0 microarrays, the entire exome expression profile of immature CD34+ HSPC and mature whole blood cells was mapped,

SUBMITTER: Tondeur S 

PROVIDER: S-EPMC2813875 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature