Reaction discovery enabled by DNA-templated synthesis and in vitro selection.

ABSTRACT: Current approaches to reaction discovery focus on one particular transformation. Typically, researchers choose substrates based on their predicted ability to serve as precursors for the target structure, then evaluate reaction conditions for their ability to effect product formation. This approach is ideal for addressing specific reactivity problems, but its focused nature might leave many areas of chemical reactivity unexplored. Here we report a reaction discovery approach that uses DNA-templated organic synthesis and in vitro selection to simultaneously evaluate many combinations of different substrates for bond-forming reactions in a single solution. Watson-Crick base pairing controls the effective molarities of substrates tethered to DNA strands; bond-forming substrate combinations are

SUBMITTER: Kanan MW 

PROVIDER: S-EPMC2814052 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature