Genetic networks controlling retinal injury.

ABSTRACT:

Purpose

The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury.

Methods

A group of acute phase genes expressed in diverse nervous system tissues was defined by combining microarray results from injury studies from rat retina, brain, and spinal cord. Genomic loci regulating the brain expression of acute phase genes were identified using a panel of BXD recombinant inbred (RI) mouse strains. Candidate upstream regulators within a locus were defined using single nucleotide polymorphism databases and promoter motif databases.

Results

The acute phase response of rat retina, brain, and spinal cord was dominated by transcription factors. Three genomic loci control transcript expression of acute phase genes in brains of

SUBMITTER: Vazquez-Chona FR 

PROVIDER: S-EPMC2814057 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature