Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

ABSTRACT: The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.

SUBMITTER: Herath A 

PROVIDER: S-EPMC2814065 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature