Vaccinia virus-specific molecular signature in atopic dermatitis skin.

ABSTRACT:

Background

Eczema vaccinatum (EV), a disseminated viral skin infection, is a life-threatening complication of vaccinia virus (VV) inoculation in patients with atopic dermatitis (AD) and is thought to be associated with a defective innate immune response. However, the precise mechanism or mechanisms and key factor or factors of EV are unknown.

Objective

Given that patients with psoriasis, another inflammatory skin disorder, are not susceptible to EV, we compared the global transcriptional response of skin to VV in healthy subjects, patients with psoriasis, and patients with AD, focusing on AD-specific genes. We hypothesized that differences in the transcriptional response to VV between patients with AD and patients with psoriasis or healthy subjects would identify a defective

SUBMITTER: Grigoryev DN 

PROVIDER: S-EPMC2814071 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature