Reduced task-related suppression during semantic repetition priming in schizophrenia.

ABSTRACT: Few studies have reported the reduced suppression of brain activity within the default network in schizophrenia. The relationship, however, between task-specific activation and default network suppression, as well as impact of this relationship on brain function, is still not clear, and it has not been studied in schizophrenia so far. We used previously published data showing a relationship between semantic encoding and white matter integrity in schizophrenia (Jeong et al., 2009), and reanalyzed the data using an independent component analysis (ICA). Participants comprised 10 healthy control subjects and 10 patients with chronic schizophrenia who underwent an fMRI scan during which they performed the Levels of Processing paradigm. The semantic processing-related independent components were

SUBMITTER: Jeong B 

PROVIDER: S-EPMC2814888 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature