A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.

ABSTRACT: Migraine is a neurovascular disorder that induces debilitating headaches associated with multiple symptoms including facial allodynia, characterized by heightened responsivity to normally innocuous mechanical stimuli. It is now well accepted that immune activation and immune-derived inflammatory mediators enhance pain responsivity, including the trigeminal system. Nociceptive ("pain" responsive) trigeminal nerves densely innervate the cranial meninges. We have recently proposed that the meninges may serve as a previously unidentified, key interface between the peripheral immune system and the CNS with potential implications for understanding underlying migraine mechanisms. Our focus here is the development of a model for facial allodynia associated with migraine. We developed a model where

SUBMITTER: Wieseler J 

PROVIDER: S-EPMC2814932 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature