Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors.

ABSTRACT: Microbicides are women-controlled prophylactics for sexually transmitted infections. The most important class of microbicides target HIV-1 and contain antiviral agents formulated for topical vaginal delivery. Identification of new viral entry inhibitors that target the HIV-1 envelope is important because they can inactivate HIV-1 in the vaginal lumen before virions can come in contact with CD4+ cells in the vaginal mucosa. Carbohydrate binding agents (CBAs) demonstrate the ability to act as entry inhibitors due to their ability to bind to glycans and prevent gp120 binding to CD4+ cells. However, as proteins they present significant challenges in regard to economical production and formulation for resource-poor environments. We have synthesized water-soluble polymer CBAs that contain multip

SUBMITTER: Jay JI 

PROVIDER: S-EPMC2815106 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature