Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria.

ABSTRACT:

Introduction

The HIV-1 epidemic in African countries is largely due to non-B HIV-1 subtypes. Patterns and frequency of antiretroviral drug resistance mutations observed in these countries may differ from those in the developed world, where HIV-1 subtype B predominates.

Methods

HIV-1 subtype and drug resistance mutations were assayed among Nigerian patients with treatment failure on first-line therapy (plasma HIV RNA >1000 copies/mL). Sequence analysis of the reverse transcriptase and protease gene revealed drug resistance mutations and HIV-1 viral subtype. Specific patterns of mutations and clinical characteristics are described in patients with the K65R mutation.

Results

Since 2005, 338 patients were evaluated. The most prevalent subtypes were CRF02_AG [152 of 338 (4

SUBMITTER: Hawkins CA 

PROVIDER: S-EPMC2815152 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature