Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions.

ABSTRACT:

Background

Screening for colorectal cancer (CRC) has shown to reduce cancer-related mortality, however, acceptance and compliance to current programmes are poor. Developing new, more acceptable non-invasive tests for the detection of cancerous and precancerous colorectal lesions would not only allow preselection of individuals for colonoscopy, but may also prevent cancer by removal of precancerous lesions.

Methods

Plasma from 128 individuals (cohort I - exploratory study: 73 cases / 55 controls) was used to test the performance of a single marker, SEPT9, using a real-time quantitative PCR assay. To validate performance of SEPT9, plasma of 76 individuals (cohort II - validation study: 54 cases / 22 controls) was assessed. Additionally, improvement of predictive capability con

SUBMITTER: Tanzer M 

PROVIDER: S-EPMC2816214 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature