Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene.

ABSTRACT:

Background

There is a need to develop robust and clinically applicable gene expression signatures. Hypoxia is a key factor promoting solid tumour progression and resistance to therapy; a hypoxia signature has the potential to be not only prognostic but also to predict benefit from particular interventions.

Methods

An approach for deriving signatures that combine knowledge of gene function and analysis of in vivo co-expression patterns was used to define a common hypoxia signature from three head and neck and five breast cancer studies. Previously validated hypoxia-regulated genes (seeds) were used to generate hypoxia co-expression cancer networks.

Results

A common hypoxia signature, or metagene, was derived by selecting genes that were consistently co-expressed with t

SUBMITTER: Buffa FM 

PROVIDER: S-EPMC2816644 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature