Mutation analysis of the MSMB gene in familial prostate cancer.

ABSTRACT:

Background

MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant. The MSMB protein is underexpressed in PrCa and it was previously proposed to be an independent marker for the recurrence of cancer after radical prostatectomy.

Methods

In this study, the coding region of this gene and 1500 bp upstream of the 5'UTR has been sequenced in germline DNA in 192 PrCa patients with family history. To evaluate the possible effects of these variants we used in silico analysis.

Results

No deleterious mutations were identified, how

SUBMITTER: Kote-Jarai Z 

PROVIDER: S-EPMC2816656 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature