C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is one of the most common causes of cancer death worldwide. Using cDNA microarray containing 23 040 genes, we earlier investigated gene-expression profiles in 11 colorectal cancers for the purpose of better understanding of colorectal carcinogenesis as well as development of novel diagnostic and therapeutic strategies. MRG-binding protein (MRGBP) or C20orf20, encoding a subunit of TRRAP/TIP60-containing histone acetyltransferase complex, was up-regulated in the majority of colorectal tumours.

Methods and results

The elevated expression of MRGBP was observed in colorectal cancer tissues by quantitative PCR as well as immunohistochemical analyses. MRGBP marginally expressed in normal vital organs. Notably, suppressed MRGBP expression by MRGBP short

SUBMITTER: Yamaguchi K 

PROVIDER: S-EPMC2816663 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature