Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs.

ABSTRACT: The declaration of the human influenza A pandemic (H1N1) 2009 (H1N1/09) raised important questions, including origin and host range [1], [2]. Two of the three pandemics in the last century resulted in the spread of virus to pigs (H1N1, 1918; H3N2, 1968) with subsequent independent establishment and evolution within swine worldwide [3]. A key public and veterinary health consideration in the context of the evolving pandemic is whether the H1N1/09 virus could become established in pig populations [4]. We performed an infection and transmission study in pigs with A/California/07/09. In combination, clinical, pathological, modified influenza A matrix gene real time RT-PCR and viral genomic analyses have shown that infection results in the induction of clinical signs, viral pathogenesis restric

SUBMITTER: Brookes SM 

PROVIDER: S-EPMC2816721 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature