G protein coupled receptors in embryonic stem cells: a role for Gs-alpha signaling.

ABSTRACT:

Background

Identification of receptor mediated signaling pathways in embryonic stem (ES) cells is needed to facilitate strategies for cell replacement using ES cells. One large receptor family, largely uninvestigated in ES cells, is G protein coupled receptors (GPCRs). An important role for these receptors in embryonic development has been described, but little is known about GPCR expression in ES cells.

Methodology/principal findings

We have examined the expression profile of 343 different GPCRs in mouse ES cells demonstrating for the first time that a large number of GPCRs are expressed in undifferentiated and differentiating ES cells, and in many cases at high levels. To begin to define a role for GPCR signaling in ES cells, the impact of activating Gs-alpha, one of the m

SUBMITTER: Layden BT 

PROVIDER: S-EPMC2816999 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature