SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects about five million people worldwide. Diagnosis remains clinical, based on phenotypic patterns. The discovery of laboratory markers that will enhance diagnostic accuracy, allow pre-clinical detection and tracking of disease progression is critically needed. These biomarkers may include transcripts with different isoforms.

Methodology/principal findings

We performed extensive analysis on 3 PD microarray experiments available through GEO and found that the RNA splicing gene SRRM2 (or SRm300), sereine/arginine repetitive matrix 2, was the only gene differentially upregulated among all the three PD experiments. SRRM2 expression was not changed in the blood of other neurological diseased p

SUBMITTER: Shehadeh LA 

PROVIDER: S-EPMC2817002 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature