Eukaryotic DING proteins are endogenous: an immunohistological study in mouse tissues.

ABSTRACT:

Background

DING proteins encompass an intriguing protein family first characterized by their conserved N-terminal sequences. Some of these proteins seem to have key roles in various human diseases, e.g., rheumatoid arthritis, atherosclerosis, HIV suppression. Although this protein family seems to be ubiquitous in eukaryotes, their genes are consistently lacking from genomic databases. Such a lack has considerably hampered functional studies and has fostered therefore the hypothesis that DING proteins isolated from eukaryotes were in fact prokaryotic contaminants.

Principal findings

In the framework of our study, we have performed a comprehensive immunological detection of DING proteins in mice. We demonstrate that DING proteins are present in all tissues tested as isoforms o

SUBMITTER: Collombet JM 

PROVIDER: S-EPMC2817009 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature