Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.

ABSTRACT:

Purpose

To investigate the association and ethnic heterogeneity of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG) and other types of glaucoma.

Methods

We performed meta-analysis and ethnicity-based subgroup analyses according to published studies. Allele and genotype frequencies of SNPs rs1048661, rs2165241, and rs3825942 were extracted for analysis in Reviewer Manager: (1) comparison of the allelic distributions between XFS and XFG, (2) allelic association of LOXL1 SNPs with XFS/XFG, (3) associations in homozygote, heterozygote, and dominant and recessive models, and (4) allelic association with primary open angle glaucoma (POAG).

Results

In total 24 reported articles were retrieved, incl

SUBMITTER: Chen H 

PROVIDER: S-EPMC2817013 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature