Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study.

ABSTRACT:

Objective

To assess whether use of the antidepressant venlafaxine is associated with an increased risk of sudden cardiac death or near death compared with other commonly used antidepressants.

Design

Population based observational study.

Setting

We did a nested case-control analysis within a new user cohort formed using the United Kingdom General Practice Research Database.

Participants

New users of venlafaxine, fluoxetine, citalopram, or dosulepin on or after 1 January 1995, aged 18 to 89 years, with a diagnosis of depression or anxiety. Participants were followed-up until February 2005, or the occurrence of sudden cardiac death or near death, identified from medical records indicating non-fatal acute ventricular tachyarrhythmia, sudden death due to cardiac cau

SUBMITTER: Martinez C 

PROVIDER: S-EPMC2817047 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature