Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates.

ABSTRACT: Since Haldane first noticed an excess of paternally derived mutations, it has been considered that most mutations derive from errors during germ line replication. Miyata et al. (1987) proposed that differences in the rate of neutral evolution on X, Y, and autosome can be employed to measure the extent of this male bias. This commonly applied method assumes replication to be the sole source of between-chromosome variation in substitution rates. We propose a simple test of this assumption: If true, estimates of the male bias should be independent of which two chromosomal classes are compared. Prior evidence from rodents suggested that this might not be true, but conclusions were limited by a lack of rat Y-linked sequence. We therefore sequenced two rat Y-linked bacterial artificial chromosom

SUBMITTER: Pink CJ 

PROVIDER: S-EPMC2817397 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature