Correlated changes between regulatory cis elements and condition-specific expression in paralogous gene families.

ABSTRACT: Gene duplication is integral to evolution, providing novel opportunities for organisms to diversify in function. One fundamental pathway of functional diversification among initially redundant gene copies, or paralogs, is via alterations in their expression patterns. Although the mechanisms underlying expression divergence are not completely understood, transcription factor binding sites and nucleosome occupancy are known to play a significant role in the process. Previous attempts to detect genomic variations mediating expression divergence in orthologs have had limited success for two primary reasons. First, it is inherently challenging to compare expressions among orthologs due to variable trans-acting effects and second, previous studies have quantified expression divergence in terms o

SUBMITTER: Singh LN 

PROVIDER: S-EPMC2817486 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature