An "in-depth" description of the small non-coding RNA population of Schistosoma japonicum schistosomulum.

ABSTRACT: Parasitic flatworms of the genus Schistosoma are the causative agents of schistosomiasis, which afflicts more than 200 million people yearly in tropical regions of South America, Asia and Africa. A promising approach to the control of this and many other diseases involves the application of our understanding of small non-coding RNA function to the design of safe and effective means of treatment. In a previous study, we identified five conserved miRNAs from the adult stage of Schistosoma japonicum. Here, we applied Illumina Solexa high-throughput sequencing methods (deep sequencing) to investigate the small RNAs expressed in S. japonicum schistosomulum (3 weeks post-infection). This has allowed us to examine over four million sequence reads including both frequently and infrequently represe

SUBMITTER: Wang Z 

PROVIDER: S-EPMC2817716 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature