Schistosoma mansoni Stomatin like protein-2 is located in the tegument and induces partial protection against challenge infection.

ABSTRACT:

Background

Schistosomiasis affects more than 200 million individuals worldwide, with a further 650 million living at risk of infection, constituting a severe health problem in developing countries. Even though an effective treatment exists, it does not prevent re-infection, and the development of an effective vaccine still remains the most desirable means of control for this disease.

Methodology/principal findings

Herein, we report the cloning and characterization of a S. mansoni Stomatin-like protein 2 (SmStoLP-2). In silico analysis predicts three putative sites for palmitoylation (Cys11, Cys61 and Cys330), which could contribute to protein membrane association; and a putative mitochondrial targeting sequence, similar to that described for human Stomatin-like protein 2 (Hu

SUBMITTER: Farias LP 

PROVIDER: S-EPMC2817717 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature