Comparison of breast cancer to healthy control tissue discovers novel markers with potential for prognosis and early detection.

ABSTRACT: This study was initiated to identify biomarkers with potential value for the early detection of poor-outcome breast cancer. Two sets of well-characterized tissues were utilized: one from breast cancer patients with favorable vs. poor outcome and the other from healthy women undergoing reduction mammaplasty. Over 46 differentially expressed genes were identified from a large list of potential targets by a) mining publicly available expression data (identifying 134 genes for quantitative PCR) and b) utilizing a commercial PCR array. Three genes show elevated expression in cancers with poor outcome and low expression in all other tissues, warranting further investigation as potential blood markers for early detection of cancers with poor outcome. Twelve genes showed lower expression in cancer

SUBMITTER: Schummer M 

PROVIDER: S-EPMC2817747 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature