Comparison of subjective and objective hot flash measures over time among breast cancer survivors initiating aromatase inhibitor therapy.

ABSTRACT:

Objective

Hot flashes are valuable indicators of physiological condition and drug effect; however, subjective and objective measures do not always agree. No study has examined both subjective and objective hot flashes in women prescribed aromatase inhibitors. The study (1) compared subjective and objective hot flash measures, (2) examined changes in subjective and objective hot flashes over time, and (3) evaluated predictors of change in hot flashes in aromatase inhibitor-treated women.

Methods

Participants (n = 135) were enrolled in a randomized clinical trial comparing exemestane and letrozole for the treatment of breast cancer. Hot flashes were assessed before the start of the drug therapy and 1, 3, and 6 months later. Participants wore a sternal skin conductance monitor

SUBMITTER: Otte JL 

PROVIDER: S-EPMC2817995 | biostudies-literature | 2009 Jul-Aug

REPOSITORIES: biostudies-literature