Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease.

ABSTRACT:

Objective

Dysfunction within corticostriatal dopaminergic neurocircuitry has been implicated in neuropsychiatric symptoms associated with Alzheimer disease (AD). This study aimed to test the hypothesis that the symptom domains delusions and apathy would be associated with striatal dopamine (D2) receptor function in AD.

Methods

In vivo dopamine (D2/D3) receptor availability was determined with [(11)C]raclopride (RAC) PET in 23 patients with mild and moderate probable AD. Behavioral symptoms were measured using the Neuropsychiatric Inventory and the Apathy Inventory. Imaging data were analyzed using a region-of-interest approach. The potential confounding effects of age, sex, and disease stage were explored using a linear mixed model. Correlational and independent samples comp

SUBMITTER: Reeves S 

PROVIDER: S-EPMC2818181 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature