Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 6. Redox properties.

ABSTRACT: Cyclic nitrones have been employed for decades as spin trapping reagents for the detection and identification of transient radicals, and have been employed as pharmacological agent against ROS-mediated toxicity. The short half-life of the nitrone-superoxide adducts limits the application of nitrones in biological millieu, and therefore investigaton of the redox properties of the superoxide adducts is important. Moreover, computational investigation of the redox properties of the nitrones and their corresponding spin adducts may provide new insights into the nature of their pharmacological activity against ROS-induced toxicity. In general, electron-withdrawing group substitution at the C-5 position results in higher EAs and IPs making these substituted nitrones more susceptible to reduction

SUBMITTER: Villamena FA 

PROVIDER: S-EPMC2818661 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature